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Tuesday, February 8, 2011

Rib-X moves skin infection treatment to Phase 2b trial

By Michelle Lang

Rib-X Pharmaceuticals Inc., an antibiotics company in New Haven, Conn., has begun a Phase 2b clinical trial of its treatments for acute bacterial skin and skin structure infections (ABSSSI).

The treatments – delafloxacin, linezolid and vancomycin – will be tested on 240 participants to help the company design Phase 3 clinical studies. The Phase 2b study is expected to show responses of the treatment on cellulitis/erysipelas, wound infection, major cutaneous abscess or burn infection.

The three drugs will also be measured as treatments for methicillin-resistant Staphylococcus aureus (MRSA).

“To complement this study, we plan to initiate a Phase 1 study later in the year to assess the Phase 3 oral formulation,” said Rib-X president and CEO Mark Leuchtenberger in a press release.

Last month, Rib-X submitted a regulatory filing, indicating that it had taken in $5.5 million of a planned $22 million offering combining debt, warrants and options.

Rib-X was founded in 2001 by Yale University colleagues Peter Moore, William Jorgensen and Thomas Steitz, winner of a portion of the 2009 Nobel Prize in Chemistry for his work describing the structure and function of the ribosome.


 

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