Digg icon reddit icon Stumbleupon icon
Print Email     Print Edition Stories

Thursday, March 5, 2009

Alnylam. MIT show data on new nanoparticles

By Marc Songini

Alnylam Pharmaceuticals Inc., an RNA interference (RNAi) drug maker, is highlighting new research around a particular class of organic molecules that can be formed into nanoparticles.

Lipidoids are a new class of lipid-based molecules that can be formed into new nanoparticle compounds for systemic delivery of RNAi treatments. Cambridge-based Alnylam (Nasdaq: ALNY) announced it had published new data in a scientific journal, with collaborators from the David H. Koch Institute for Integrative Cancer Research at MIT. The new research shows indications of how to craft delivery mechanisms more precisely for small interfering RNAs (siRNAs), the molecules that mediate RNAi.
 
Alnylam’s and its partners’ research increased the understanding how lipidoids function and may help Alynlam as it seeks to maximize RNAi’s in vivo effectiveness. The researchers learned how to understand the long-term stability of a formulation and how to identify key parameters affecting the pharmacodynamics involved.

Researchers also showed that lipidoid formulations achieve delivery of more than 90 percent of the administered siRNA dose to the liver, while maintaining in vivo activity after several months of repeated administration. 

Last January,  Alnylam won U.S. Food and Drug Administration clearance to begin enrolling patients for its Phase 1 study of a liver cancer treatment.

Digg icon reddit icon Stumbleupon icon
Contact Editor Latest News

Comments

Please Login/Register to post comments.

No comments have been added or approved.

On the MHT blog now

Women to Watch: What makes them special

By James M. Connolly Intelligence, dedicated, leader, innovative, hard-working — they’re all words associated with the 11 women recognized with the Mass High Tech Women to Watch awards this morning. But back at the office we were talking how commonly another word has to be applied to the 2010 honorees and their 60 predecessors. It’s their humility. It’s so striking. We at Mass High T...

Read More

Most Popular Stories
EmailedViewed
Stay Informed
Check which newsletter you'd like to receive.
TechFlash (Daily)
FinanceFlash (Daily)
BioFlash (Daily)
GreenFlash (Weekly)
Startup Report (Weekly)
Breaking news, MHT events, local announcements
RSS feeds
Your email:

Affiliate publications: ACBJ.com, Boston Business Journal, Bizjournals.com, Portfolio.com, Wired.com

Web Site Developed by Neptune Web, Inc.

Use of, registration on, this site constitutes acceptance of our User Agreement. Please read our Privacy Policy (updated) A publishing partner with Portfolio