Posts Tagged ‘Julie Donnelly’

Invo Bioscience births a wailing med device success

Friday, October 9th, 2009

By Julie Donnelly

Julie DonnellyInvo Bioscience has a very special announcement to make — it is the proud parent of a fertility device that has produced its first baby.

The Beverly-based medical device firm’s Invocell device was launched in the Middle East early this year, and a healthy baby arrived on September 29 to a Pakistani mother. The mother, who is 40, was trying to get pregnant for 16 years.

The procedure involves combining sperm and eggs in a device that is implanted in the woman for three days to incubate. Then one or two resulting embryos are transferred to the uterus so it can implant and the pregnancy can continue.

The announcement is sweet because in the life sciences, tangible results are few and far between. Creating a drug, for instance, takes at least ten years and up to $1 billion. For medical devices, the FDA approval process is somewhat quicker and easier. But researchers and company executives alike still must possess tremendous patience and stamina getting life science products to market. There are many more failures than successes. And success is often measured in little increments, such as extending the life of a cancer patient for a few weeks.

But you can’t be a little pregnant. A woman in Pakistan can now happily attest to that.

Kudos, Invo Bioscience.

Antigen Express synthetic H1N1 flu vaccine in the works

Friday, September 25th, 2009

By Julie Donnelly

Julie Donnelly

Worcester-based synthetic vaccine company Antigen Express Inc. is hard at work making the next generation of vaccines against both avian and swine flu.

The company wasn’t among the five pharmaceutical giants to be approved to produce the H1N1 vaccine that will be distributed throughout the U.S. in the next few weeks. In fact, Antigen Express is still waiting for the FDA to approve protocols for clinical trials of its H1N1 vaccine — company President Eric von Hofe said he expects those conversations to happen in the next few weeks. Von Hofe said the company is currently doing trials in Lebanon and is seeking approval to do clinical trials from European Union regulators as well.

The FDA has never approved a synthetic vaccine for prophylactic use. But von Hofe said that he thinks the regulator is starting to warm up to the novel technology.

“Back when there was the H5N1 (avian flu) scare, the FDA was very skeptical of synthetic vaccines. But then they tried to make a vaccine out of eggs and they just couldn’t do it because it was so toxic. Now I think they may be more open new technologies,” von Hofe said.

Antigen Express uses a combination of three peptides, which are strands of linked amino acids, to develop its vaccines. Von Hofe said the company discovered that one of the peptides the company is using for its H5N1 vaccine, also in development, is from a part of the virus that is identical with H1N1. So now the company has to identify the other two peptides for the combination, get approval from U.S. and/or EU regulators to start trials and do the trials. This whole process should take more than a year, which means the company won’t be a player in this year’s fight against pandemic flu.

… Unless things go horribly, horribly wrong. Von Hofe said that if the swine flu mutates halfway through the season, and the vaccines being manufactured now are ineffective, the government could push up the time lines for other vaccines in development, including, perhaps, Antigen Express’ vaccine.

MHT on NECN: Brightcove, PermissionTV change strategies

Monday, September 21st, 2009

Staff writer Julie Donnelly dropped by New England Business Day to talk about local online video companies like PermissionTV and Brightcove — rumored to be bought by Google last week — targeting smaller publishers of Web video.

Biotech funding: Aim for balance or tip the scale?

Wednesday, August 26th, 2009

The number of Massachusetts residents working in the biotech industry has reached an all-time high, according to new data compiled by the Massachusetts Biotechnology Council. The number of biotech workers in 2008 was 45,905, up just slightly from the year before, but up 42.6 percent over the past seven years.

And when politicos talk about bringing good-paying jobs to the state, this is what they mean: the average biotech salary is $89,829, a huge raise from the average salary across all sectors in Massachusetts, which is $51,151.

Massachusetts got a slightly smaller slice of the venture capital pie for the first half of 2009, winning about 18 percent of all biotech VC funding across the country, down from 20 percent last year. But Massachusetts remains the second-best funded state, after California, when it comes to VC investment in biotech. (more…)

MHT on NECN: Biotechs launch despite recession

Tuesday, August 18th, 2009

Staff writer Julie Donnelly talked to New England Business Day about a few startups that have launched despite the sorry state of the economy for life sciences firms.

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